![]() Robert MacLaren is Professor of Ophthalmology at the University of Oxford, Consultant Ophthalmologist at the Oxford Eye Hospital, Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology, Honorary Consultant Vitreoretinal Surgeon at Moorfields Eye Hospital and an NIHR Senior Investigator. Professor of Ophthalmology at the University of Oxford, Consultant Ophthalmologist at the Oxford Eye Hospital, Honorary Professor of Ophthalmology at the UCL Institute of Ophthalmology, Honorary Consultant Vitreoretinal Surgeon at Moorfields Eye Hospital and an NIHR Senior Investigator ![]() Her research is focussed on disease mechanisms, complement therapeutics (target validation, indication validation, drug discovery) and complement biomarkers (diagnosis, stratification). She is currently based at Newcastle University and the National Renal Complement Therapeutics Centre (NRCTC, Royal Victoria Infirmary, Newcastle). Subsequent dissection of functional consequences of common AMD-linked polymorphisms led to the concept of the ‘complotype’ -the influence of complement genetic makeup on inflammation & infection. With collaborators in Madrid, she was the first to characterise ‘gain-of-function’ mutations in the complement activating proteins, C3 and factor B, explaining their association with renal disease. She has a keen interest in structure-function relationships in complement activators and regulators with a particular focus in the mechanisms underlying complement dysregulation and disease. ![]() ![]() She has been studying complement for more than 30 years with experience in both academia and Pharma. Professor of Molecular Immunology, Newcastle University, UKĬlaire Harris is Professor of Molecular Immunology at Newcastle University. ![]()
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